Curricular Unit:Code:
Pharmaceutical Chemistry II843QFR2
3MasterPharmaceutical Sciences4 ects
Learning Period:Language of Instruction:Total Hours:
Winter SemesterPortuguese/English52
Learning Outcomes of the Curricular Unit:
The curricular unit of Pharmaceutical Chemistry II presents a multidisciplinary approach based on the application of Chemistry principles to the study of biologically active compounds used in current therapeutics. Its main objective is the study of the chemical structures, methods of production, structure-activity relationships, metabolism and applications of several drug groups.
Students should acquire the following skills:
- Understand the precursor chemical groups of a large number of chemotherapeutic drugs (antibacterial, antifungal, antiviral, antineoplastic) and antihypertensive drugs;
- Understand the general principles of their structure-activity relationships;
- Understand the mechanisms of action of the mentioned pharmacotherapeutic groups, justifying them at a molecular level;
- To be able to justify and explain the occurrence of resistance to chemotherapeutic agents;
- Be able to plan and execute the chemical control of several pharmaceutical specialties.
1. Chemotherapeutic Agents:
1.1. Introduction
1.2. Antiseptics and disinfectants
1.3. Antibacterials for systemic use:
1.3.1. Sulfonamides
1.3.2. Quinolones
1.3.3. beta -lactam antibiotics
1.3.4. Tetracyclines
1.3.5. Aminoglycosides
1.3.6. Macrolides
1.4. Antifungals:
1.4.1. Polyene antibiotics
1.4.2. Azole derivatives
1.4.3. Allylamines
1.4.4. Echinocandins
1.5. Antivirals:
1.5.1. Strategies for antiviral chemotherapy
1.5.2. Classification of antivirals according to their chemical structure
1.5.3. Inhibitors of viral DNA polymerase
1.5.4. Anti-HIV drugs
1.5.5. Anti-influenza drugs
1.6. Antineoplastic agents:
1.6.1. Drugs that act directly on DNA: Alkylating agents Chelating Agents
1.6.2. Drugs with intervention in DNA synthesis - antimetabolites
1.6.3. Drugs with intervention in the mitotic phase
2. Antihypertensive Agents:
2.1. Renin-angiotensin-aldosterone axis modifiers
2.2. Diuretics
2.3. Calcium channel blockers
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
Defined syllabus of the Medicinal Chemistry II CU are objectively focused on the most relevant aspects of the discovery and development of some pharmacotherapeutic drug groups. Students will be focused on understanding and reflecting on the discovery, development, structure-activity relationships and mechanisms of action and mechanisms of resistance at a molecular level of the selected drugs. The PL content aims to give students a basis for the chemical control of pharmaceutical products.
Teaching Methodologies (Including Evaluation):
Pedagogic execution of the theoretical classes: presentation of relevant theoretical concepts in the classroom, practical application of some concepts, orientation of student’s self-study by analysis of recommended bibliography. Debate on actual and pertinent issues.
Pedagogic execution of the laboratorial classes: preparation, execution and discussion of the foreseen laboratorial protocols.
Theoretical- Two summative assessment tests, 2 h (50% each of the final grade). The student must obtain an average of 9.5 or above.
Practice- Two summative assessment tests, 2 h (30% each of the final grade) + execution of the experimental protocols and completion of the respective forms (40% of the final grade). The student must obtain an average of 9.5 or above.
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
The teaching methodologies adopted in the teaching / learning process allow full integration of the contents previously defined in the syllabus of each component (T, PL), which is a much desirable point according to the intended learning outcomes.
1 - Patrick, G.L. An Introduction to Medicinal Chemistry, 6th Edition, Oxford, 2021.ISBN-13:978-0198749691.
2 - Avendaño C. e Menéndez, J.C. Medicinal Chemistry of Anticancer Drugs, 2nd Edition, Elsevier Science, 2015. ISBN: 9780444626493.
3 - Avendaño C. Introduccion a la Química Farmacêutica, 2nd Ed, McGraw-Hill Interamericana, 2001. ISBN-13:978-8448603618.
4 - Farmacopeia Portuguesa IX – Edição oficial, INFARMED, Lisboa, 2008.
6 - Farmacopeia Britânica, British Pharmacopoeia Organisation, Londres, 2002.
7 - Souto, R.; Pimenta, A. e Catarino, R. Manual Prático de Análise Química, 1ª Edição, Lusodidacta, 2018.
Lecturer (* Responsible):
Rita Catarino (