Curricular Unit:			Code:
Pharmaceutical Chemistry I			843QFR1
Year:	Level:	Course:	Credits:
2	Master	Pharmaceutical Sciences	4 ects
Learning Period:		Language of Instruction:	Total Hours:
Spring Semester		Portuguese/English	52
Learning Outcomes of the Curricular Unit:
The main objective of this course is to provide students with knowledge of pharmacologically active substances used in current therapy. Its scope covers the discovery, design, identification and synthesis of biologically active compounds, the study of drug metabolism and interpretation of their mode of action at the molecular level and the establishment of structure / activity relationships. The competencies to be achieved with the frequency of the course are: Understand the theoretical aspects of drug-receptor binding and the factors influencing it.
Syllabus:
Basic concepts. Drugs classification and nomenclature. Principles of drug action and related parameters. Pharmacokinetics and drug metabolism. Drug development: isolation from natural products, identification of the lead and molecular modification. History, structure, synthesis, mechanisms of action and metabolism of the following drugs: general anesthetics, local anesthetics, hypnotics and sedatives, anxiolytics, antidepressants, antipsychotics, anticonvulsants, narcotic analgesic drugs and non-steroidal anti inflammatory drugs.
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The syllabus integrating the module are suitable for the development of targeted skills. The aim is also to provide a solid balance between theoretical principles and practical application of skills in chemistry, focusing the discussion and resolution of problems, enabling students to develop a clearer and more critical view. We also intend to train students for correct handling of laboratory equipment and convenient execution of basic operations.
Teaching Methodologies (Including Evaluation):
The methodologies used are the expository methods and application of concepts in solving problems in the lectures. In practical classes, students perform laboratory protocols autonomously. The evaluation of the course comprises a theoretical evaluation (by continuous evaluation, with two theoretical written tests or by final exam), and a practical evaluation (student performance in the laboratory, filling out a worksheet at the end of each protocol executed, a written practical test and elaboration of a monograph on a pharmacologically active molecule) . Theoretical assessment requires a minimum of 9.5 values; practical assessment requires a minimum of 9.5 values. The intermediate and final grades are calculated to 1 decimal place and then rounded to the whole value.
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
The objectives of the curricular unit are achieved by the use of the methodology referred since the expository component provides guidance on the systematic study and the practice exercitation promotes the practical application of concepts and theories studied within the curricular unit.
Reading:
Jie Jack Li, Medicinal Chemistry for Practitioners, John Wiley & Sons Inc, 2021 Barreiro E, Mansour Fraga C A, Química Medicinal- As Bases Moleculares da Acção dos Fármacos, ArtMed Editora, 2008- 2ª Ed Wilson and Gisvold´s Textbook of Organic Medicinal and Pharmaceutical Chemistry, Ed. J. Block, J. Beale Jr., 12th Ed, 2011 Patrick, G.L. An Introduction to Medicinal Chemistry, 6th Edition, Oxford, 2017