Curricular Unit:			Code:
Organic Pharmaceutical Chemistry II			1202QFO2
Year:	Level:	Course:	Credits:
2	Master	Pharmaceutical Sciences	6 ects
Learning Period:		Language of Instruction:	Total Hours:
Spring Semester		Portuguese/English	78
Learning Outcomes of the Curricular Unit:
Pharmaceutical Chemistry is a multidisciplinary field that applies chemical principles to the investigation of biologically-active substances that include therapeutically useful drugs, natural products, toxins and drugs of abuse. Pharmaceutical Chemistry II is committed to providing a thorough understanding of pharmacological active substances commonly used in nowadays therapy. The discipline’s main objective is the study of chemical structure, synthetic pathways, mechanisms of action, metabolism, pharmacokinetics and structure-activity relationship of several classes of drugs. Some analytical procedures used in the identification and in the quantification of the studied drugs are also approached.
Syllabus:
1. Chemoterapeutic Agents 1.1. Introduction 1.2. Antiseptics and Disinfectants 1.3. Antibiotics 1.4. Antifungal Agents 1.5. Antiviral Agents 1.6. Antineoplastic Agents 2. Steroids and related compounds 2.1. Corticosteroids: Agonists and Antagonists 2.2. Mineralocorticoids e glucocorticoids 2.3. Sexual Hormones: androgens, estrogens and progestagens, agonists and antagonists 2.4. Steroids as anticancer agents 3. Antihistaminic agents 3.1. Introduction 3.2. H1 Antagonists 3.3. H2 Antagonists 4. Cardiovascular agents 4.1. Introduction 4.2. Antihypertensive Agents
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The syllabus integrating the curricular unit are suitable for the development of targeted skills because there is a balance between transmitted theoretical concepts and the theoretical-practical application of these on interpreting and solving problems related to selected bioactive molecules. In the laboratory component, students learn to interpret the pharmacopoeia monographs and conducting pharmacopoeia analysis.
Teaching Methodologies (Including Evaluation):
Explanation of main theoretical concepts and guidance for autonomous study will be given in theoretical classes. The students will be guided through the execution of a a series of practical exercises including questions of objective answer and of structured answer according to pre-established aims. Practical classes include the execution of a series of experimental works whose completion will demonstrate some of the concepts studied in the theoretical classes. The theoretical component will be evaluated through the execution of two tests (with a weighing coefficient of 80%). The practical component will be evaluated through the execution of two tests and several reports about the practical work developed (with a weighing coefficient of 20%).
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
The objectives of the curricular unit are achieved by the use of the referred methodology since the expository component allows the acquisition of knowledge necessary for understanding the connection between the chemical structure of a drug and its therapeutic action, its mechanism of action, pharmacokinetics and metabolism. In practical classes students can perform some analytical methodologies in order to identify and quantify some selected drugs in several pharmaceutical formulations.
Reading:
1 - Patrick, G.L. An Introduction to Medicinal Chemistry, 5ª Edição, Oxford, 2013. 2 - Avendaño C. Introduccion a la Química Farmacêutica, McGraw-Hill Interamericana, 2004 3 - Avendaño C. e Menéndez, J.C. Medicinal Chemistry of Anticancer Drugs, 1ª Edição, Elsevier, 2008. 4 -Farmacopeia Portuguesa IX – Edição oficial, INFARMED, Lisboa, 2008.