Curricular Unit:			Code:
Organic Pharmaceutical Chemistry I			1202QFO1
Year:	Level:	Course:	Credits:
2	Master	Pharmaceutical Sciences	6 ects
Learning Period:		Language of Instruction:	Total Hours:
Winter Semester		Portuguese/English	78
Learning Outcomes of the Curricular Unit:
The main objective of this course is to provide the fundamental concepts about some pharmacologically active substances used in current therapy. Its scope covers the discovery, design, identification and synthesis of biologically active compounds, investigation of their metabolism, the interpretation of its mode of action at the molecular level and structure / activity relationships.
Syllabus:
Basic concepts. Drug classification and nomenclature. Principles of drug action and related parameters. Pharmacokinetics and drug metabolism. Drug development: isolation from natural products, identification of the lead and molecular modification. History, structure, synthesis, mechanisms of action and metabolism of the following drugs: general anesthetics, local anesthetics, hypnotics and sedatives, anxiolytics, antidepressants, antipsicotics, anticonvulsants, narcotic analgesic drugs, non-steroidal antiinflamatories, steroidal antiinflamatories and steroidic hormones.
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The syllabus integrating the module are suitable for the development of targeted skills. The aim is also to provide a solid balance between theoretical principles and practical application of skills in chemistry, focusing the discussion and resolution of problems, enabling students to develop a clearer and more critical view. We also intend to train students for correct handling of laboratory equipment and convenient execution of basic operations.
Teaching Methodologies (Including Evaluation):
The methodologies used are expository methods and applying concepts in problem solving. The evaluation of the course includes, in addition to continuous assessment, student performance in the lab.
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
The objectives of the curricular unit are achieved by the use of the methodology referred since the expository component provides guidance on the systematic study and the practice exercitation promotes the practical application of concepts and theories studied within the curricular unit.
Reading:
Avendaño C., Introducción a la Química Farmacéutica, Mcgraw-Hill, 2004. Barreiro E, Mansour Fraga C A, Química Medicinal- As Bases Moleculares da Acção dos Fármacos, ArtMed Editora, 2001 Wilson and Gisvold´s Textbook of Organic Medicinal and Pharmaceutical Chemistry, Ed. J. Block, J. Beale Jr., 2004 Patrick G. L., An Introduction to Medicinal Chemistry, 3rd Ed, 2005, Oxford University Press Andrejus Korolkovas, Joseph H. Burckhalter, Química Farmacêutica- Rio de Janeiro : Guanabara Koogan, 1988 Thomas, Gareth, Fundamentals of Medicinal Chemistry, Wiley, England, 2003 Patrick, Graham, An Introduction to Medicinal Chemistry, Oxford University Press, 1995
Lecturer (* Responsible):
Carla Matos (cmatos@ufp.edu.pt) Rita Catarino (ritacat@ufp.edu.pt)