Curricular Unit:			Code:
Biochemistry and Physiology			852BIFI
Year:	Level:	Course:	Credits:
1	Undergraduate	Nursing	4 ects
Learning Period:		Language of Instruction:	Total Hours:
		Portuguese/English	52
Learning Outcomes of the Curricular Unit:
In this course, the most important metabolic processes will be studied, as well as the cellular communication systems involved in the regulation of the metabolic equilibrium of an organism. The students will understand the fundamental aspects of Cellular Biochemistry, the metabolism of the major classes of nutrients and the (bio)chemistry and physiology of the endocrine system. At the same time, clinical situations related to the subject matter will be introduced, with the aim of developing criticical thinking and problem analysis skills.
Syllabus:
Lectures: 1 Metabolism 1.1 Interpretation of metabolic charts 1.2 Glycolysis 1.3 Citric acid cycle 1.4 Fermentation and Respiration 1.5 Gluconeogenesis 1.6 Pentose-phosphate pathway 1.7 Glycogen metabolism 1.8 Gluconeogenesis 1.9 Aminoacid metabolism: transamination, oxidative deamination and urea cycle 1.10 Beta-oxidation of fatty acids 1.11 Synthesis of fatty acids and ketogenesis 1.12 Integration of metabolism 2 Hormonal regulation 2.1 Basic concepts of intercellular communication 2.2 Hormones of the hypothalamus-pituitary axis, thyroid, adrenal glands, pancreas and gonads. 3 Regulation of digestion Laboratory classes: Quantifying glucose , protein and cholesterol Separation of molecules using thin-layer chromatography and ion-exchange chromatography Spectrophotometry
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The syllabus comprising the curricular unit will meet the requirements that are set out in the objectives, and it provides students with the necessary lessons (concepts, techniques, methodologies) to be able to achieve the objectives set out above.
Teaching Methodologies (Including Evaluation):
Nas aulas teóricas procede-se à exposição dos conceitos teóricos relevantes e orientação do estudo dos alunos por consulta da bibliografia recomendada. As aulas teóricas incluem ainda a discussão detalhada, com resolução de exercícios, sobre os principais temas, incluindo a análise de doenças de metabolismo, seus sintomas e relação com a(s) causa(s), e tratamentos possíveis. Nas aulas laboratoriais utilizar-se-ão técnicas bioquímicas para estudar sistemas biológicos. two written tests (80%) laboratorial skills (20%)
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
Active learning strategies, such as open discussion and guided problem-solving, allow the progressive incorporation of new concepts to the previous corpus of knowledge. The laboratory experience of of biochemical analysis techniques applies concepts and knowledge from the lectures and develops the ability to critique and reflect upon experimental data.
Reading:
(1) Devlin T.M., 2006, “Textbook of Biochemistry with clinical correlations”, 6ª. Edição, Wiley-Liss. (2) Silva P.J. “Uma panorâmica geral das vias metabólicas”, disponível online em www2.ufp.pt/~pedros/bq/integracao.htm (3) Lehninger A.L. et al., 2004, “Principles of Biochemistry”, 4ª edição, W.H. Freeman and Company, N.Y.. (4) Mckee J.R., Mckee T., 2002, “Biochemistry: the molecular bases of life”, 3ª edição, McGraw-Hill Science. (5) Vander A. et al., 2006, “Human Physiology: The mechanism of Body Function”, 10ª. edição, McGraw-Hill Science. (6) Guyton & Hall., 2005, “Textbook of Human Physiology”, 11ª edição, Saunders. (7) Cardoso et al, 2011, “Trabalhos Laboratoriais de Bioquímica”, Edições Fernando Pessoa