Curricular Unit:			Code:
Biology and Physiological Biochemistry			1077BBFI
Year:	Level:	Course:	Credits:
1	Undergraduate	Nursing	3 ects
Learning Period:		Language of Instruction:	Total Hours:
Winter Semester		Portuguese/English	39
Learning Outcomes of the Curricular Unit:
Acquire fundamental concepts of Biology and Physiological Biochemistry; To assimilate the fundamental aspects of Biology and Biochemistry and to deepen the cellular and particular domains of the metabolism of the main biomolecules; Train and relate some clinical situations with changes in the metabolic pathways studied; Describe and use the knowledge and skills of Biology and Physiological Biochemistry to provide nursing care; Acquire instruments and develop capacities for glucose measurement, mitochondrial respiration, triacylglycerol determination and quantification of total and HDL cholesterol. The competences defined by the Order of Nurses (EO) are acquired throughout the undergraduate nursing course, and their fullness is reached at the end of all theoretical and practical components.
Syllabus:
Theoretical: 1. Carbohydrate Metabolism Glycolysis Gluconeogenesis Krebs cycle Electron transport chain and oxidative phosphorylation Oxidative phosphogluconate pathway Glycogen Diseases of carbohydrate metabolism 2. Lipid Metabolism Fatty acid oxidation and synthesis Lipogenesis and mobilization of lipid deposits Ketone bodies Cholesterol Diseases of lipid metabolism 3. Amino Acid Metabolism Transamination and deamination Urea cycle Glucogenic and ketogenic amino acids Diseases of amino acid metabolismo Theoretical-Practical: 1. The chemical components of the cell 2. Structure and function of biomolecules 3. Cell: the fundamental unity of life 4. Cellular communities 5. Acellular organisms 6. Genetics and evolution Laboratorial Practical: 1. Glucose measurement 2. Mitochondrial respiration 3. Determination of triacylglycerols 4. Quantification of total and HDL cholesterol
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The syllabus of the course allows the student to understand and acquire knowledge in the area of Biology and Physiological Biochemistry. Simultaneously some metabolic diseases are presented, relating clinical situations with alterations in the studied metabolic pathways. It is also intended that students acquire and develop empirical skills by contacting with new laboratory methodologies. The contents are consistent with the objectives to be achieved by students, enabling them to integrate the knowledge of Biology and Physiological Biochemistry in nursing care.
Teaching Methodologies (Including Evaluation):
The theoretical and practical classes will use the method interrogative, expository and demonstrative. The practical classes will be in a laboratory environment in which the interaction between theoretical and theoretical-practical classes and the laboratory environment will be done. The approach of the contents will be made using active and reflective methodologies, using exercises, case studies, analysis and discussion of problem situations. Theoretical: Two written evaluation tests that focus on the syllabus taught (T1 + T2). Theoretical-practical: Two written assessment tests that focus on the syllabus taught (TP1 + TP2). Laboratorial Practical: Four mini-tests on practical laboratory work (P1 + P2 + P3 + P4) and continuous assessment of laboratorial procedures (ACP). Final Classification = [{(T1+T2)/2} x 0,4] + [{(TP1+TP2)/2} x 0,4] + [{((P1+P2+P3+P4)/4) x 0,9) + (ACP x 0,1)} x 0,2]
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
In a first phase, it is important for students to assimilate the fundamental aspects of biology and biochemistry, and to deepen the particular domains of metabolism of major biomolecules. Thus, in the theoretical and theoretical-practical classes, students will be exposed to the concepts and orientation of the students' study by consulting the recommended bibliography. In a second phase, we intend to introduce some clinical situations related to changes in the metabolic pathways studied. For this, the lectures also include detailed discussion, with exercise resolution, on the main topics, including the analysis of metabolic disorders, their symptoms and their relationship to the cause (s), and possible treatments. It is also intended that students acquire and develop empirical skills by contacting with new laboratory methodologies. Thus, the laboratorial practical classes include the execution of practical work of application of the various theoretical concepts.
Reading:
Alberts, B., et al. (2013). Essential Cell Biology (4ª ed.). Garland Science. Azevedo, C., & Sunkel, C.E. (2012). Biologia Celular e Molecular (5ª ed.). Lidel. Berg, J.M., Tymoczko, J.L., Gatto, G.J., & Stryer, L. (2019). Biochemistry (9ª ed.). W.H. Freeman and Company. Cardoso, I.L., Leal, F., & Lemos, C. (2020). Biochemical Changes During The Human Lifespan. Cambridge Scholars Publishing. Cardoso, I.L., & Leal, F. (2013). Manual de Exercícios de Bioquímica. ed. UFP. Cardoso, I.L., Moutinho, C., Sousa e Silva, C., Lemos, C., Leal, F., & Silva, P. (2014). Trabalhos Laboratoriais de Bioquímica (3ª ed.). ed. UFP. Devlin, T.M. (2010). Textbook of Biochemistry with Clinical Correlations (7ª ed.). Wiley-Liss. Leal, F., & Cardoso, I.L. (2013). Casos Clínicos em Bioquímica. ed. UFP. Mckee, T., & Mckee, J.R. (2016). Biochemistry: the Molecular Bases of Life (6ª ed.). McGraw-Hill. Nelson, D.L., & Cox, M.M. (2017). Lehninger Principles of Biochemistry (7ª ed.). W.H. Freeman and Company.
Lecturer (* Responsible):
Fernanda Leal (fleal@ufp.edu.pt) Sofia Pereira (sofia@ufp.edu.pt)