Curricular Unit:			Code:
Immunology			146IMUN
Year:	Level:	Course:	Credits:
2	Undergraduate	Clinical Analyses and Public Health	6 ects
Learning Period:		Language of Instruction:	Total Hours:
		Portuguese	78
Learning Outcomes of the Curricular Unit:
Knowledge: The unit aims at providing the student with: comprehension of the basic mechanisms of the immune response to endogenous and exogenous aggressions; knowledge of the Immune System- organs, anatomy and cells; knowledge of the major humoral components of the IS, their molecular structure, function and mechanism of action; comprehension of Immunology of the infection; comprehension of immunodeficiencies, hypersensitivities, autoimmunities, tumors and transplants; understand immunization and immunosuppression; understand the strategies of therapeutic immunological manipulations; understand the major laboratory methods to the study of the immune system and the analytical methods of evaluation of its components. Skills and capacities: Provide the student with practical skills to design, execute, interpret and validate Clinical and Research immunology laboratory results in the área of Clinical analysys.
Syllabus:
Teoric program: basic notions of the imune system: acute phase response, inflammation, acute phase proteins and Complement system.Adaptative Immune system: T and B lymphocytes; T cells- maturaction, activation and diferentiation; T cells populations; B cells- maturation, activation and diferentiation; B cells populations; genetic diversity and immunoglobulins; Anteigen presenting cells (APC) and dendritic cells; MHC- Histocompatibility Major Complex- functions, structure and modulation; Cytokines- actions and main functions; Integrated actuation of the imune system- acute and chronic inflammation; virical, bacterial and parasitic infections- the imune response; Immunization- active and passive; Primary immunodeficiencies; phagocytic, Complement T and B; secundary immunodeficiencies; hipersensibilities type I, II, II and IV, Tumors and autoimmunity; The student, at the end, should be able to discuss the technological bases and the uses of immunological techniques in the clinical patholo
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The students should recognize the immune system and all cellular processes involved in the generation of the immune response: cells and organs. They should, progressively, be able to describe all the structural properties of the antigenic response receptors and how to manipulate them for therapeutical purposes.In the immune reaction we will explain how the infection works and the numerous imbalances of this reaction: immunodeficiency’s, hypersensitivities, tumours, autoimmunity and transplants. In paralell with the global presentation of the concepts, and, from a practical point of view they should learn the laboratory immunologic techniques to evaluate the immune response and diagnose simple pathologies. We will also focus the current investigation in Clinical analysys in the context of the discipline.
Teaching Methodologies (Including Evaluation):
Theoretical Classes- these classes will cover the totality of the programmatic contente, using the expositive method. During the teoric sessions will be incentivated the students participations, co-relating the concepts he leaned with ethical and pratical aspects of its future professional life; there will be a solid transmission of all the teoric knowledge in a progressive and contínuos form. Pratical Classes; the laboratorial works concerning the study of the immunological status will be developed with the intention to give to the sudent the adequate skills in a clinical Analysys laboratory – área of immunology. Evaluation: the evaluation used is iin the Pedagogical Regulation Manual- 60% of the final grade will result from the teorical tests ( 2 writen evaluations) medium; 40% of the final grade will result from the practical componente ( 3 Tests and 2 scientific reports)
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
Teorical Component- the student and the teacher will discuss the information exposed in the main text book, and the transmited concepts; short questions will evaluate if the student is making progresses and also the tests will evaluate its performance. The classes will be suported by periods of individual or group tutorial sessions that will satisfy the main necessities of the student. Pratical Component- The student shoul be able to adapt to the laboratorial environment and equipements used in the several immunologic diagnostic tecnhiques; he should be able to answer basic questions of the laboratory assays and develop its capacity to mantain an oral discussion, namely of cientific works in his área; he should be able to analize the recente literature and explain its importance in the investigation context.
Reading:
Fundamentos de Imunologia (2012) Autor(es) Fernando A. Arosa, Elsa M. Cardoso e Francisco C. Pacheco Arosa et al. Lidel, (2ª Edição) Kuby Immunology (2004) Autores Richard A. Goldsby, Thomas J. Kindt, Barbara A. Osborne, Janis. Freeman (5ª edição) Medical Immunology (2001) Autores Tristram G. Parslow, Daniel P. Stites, Abba I. Terr, John B. Imboden, McGraw-Hill (10º edição) Current Protocols in Immunolology (1991), Wiley Interscience, Ed John Colingan Manual of Clinical Laboratory Immunology (2002)Autor(es) Rose et al. 6th ed. ASM Press