Curricular Unit:			Code:
Pharmacology and Toxicology			1019FCTX
Year:	Level:	Course:	Credits:
1	Undergraduate	Clinical Analyses and Public Health	6 ects
Learning Period:		Language of Instruction:	Total Hours:
Spring Semester		Portuguese/English	78
Learning Outcomes of the Curricular Unit:
The main objectives of Pharmacology and toxicology are: O1- Understand the basis of pharmacology and toxicology; O2-Understand the basic and clinical pharmacokinetics and toxicokinetics; O3- Understand the general mechanisms of drugs action; O4- Knowledge of the mechanisms by which drug interactions occur, as well as interactions among drugs and plants or food; O5- Identify the drugs and where they act and allocate them to their respective group; O6- Identify adverse drug reactions and participate in pharmacovigilance; O7- Understand the general mechanisms of toxicants action and methods to evaluate their effects; O8- Acquire scientific skills for conducting and implementing laboratory analytical techniques for searching and quantifying drugs and toxicants; O9- Recognize the importance of therapeutic drug monitoring O10- Develop autonomy in the search for information regarding pharmacology and toxicology.
Syllabus:
CP1: General principles of Pharmacology and toxicology. CP2: Drugs and toxicants pathways in the body. Pharmacokinetics and toxicokinetics (absorption, distribution, metabolism and elimination). CP3: Pharmacodynamics and general mechanisms of drugs action. CP4: Drugs acting at the central nervous system: (sedative and hypnotic, antiepileptics, psychostimulants and drugs of abuse). CP5: Drugs acting on pain control: opioid analgesics and nonsteroidal anti-inflammatory drugs. CP6: Adverse drug reactions, and drug interactions and pharmacovigilance. CP7: General mechanisms of toxicants action. CP8: Risk assessment and acceptable daily intake. CP9: Pesticides and heavy metals: target organs and toxicity mechanisms. CP10: Analytical methods for detection and quantification of drugs and toxicants. CP11: Therapeutic drug monitoring. CP12: Sources of information on drug and toxicants.
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The contents comprising the curricular unit of Pharmacology and Toxicology provide the students of Clinical analysis and public health, technical and interpersonal skills to develop interventions in the field of pharmacology and toxicology. Knowing the basics of pharmacology and also the major pharmacotherapeutic groups (syllabus contents CP1 to CP6) allow the student to acquire the objectives O1, O2, O3, O4, O5, O6 and O9. The contents of toxicology and the study of several toxicants and their mechanisms of action (syllabus contents CP7 to CP9) allow the acquisition of the objectives O2, O7 and O8. Conducting analytical laboratory protocols for searching and quantifying drugs and toxicants (syllabus contents CP10 to CP12) are important for objectives O2, O3, O4, O6 and O7.
Teaching Methodologies (Including Evaluation):
Teaching Methodologies M1: Presentation and discussion of relevant theoretical concepts in the classroom M2: Brainstorm on pertinent issues related to the matter exposed and in the resolution of exercises M3: Execution of laboratory protocols using current analytical methodologies M4: Discussion of problems and relevant clinical cases. M6: Use of the e-learning platform to store and provide educational material to the student. Evaluation The assessment consists of two written tests in theoretical part (worth 60% of the final grade) and of two written tests, assay resolution and student performance in the laboratorial part (worth 40% of the final grade). If the grade of a given component is less than 9.5, the student will automatically fail that component, be it theoretical or laboratorial.
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
The constant interaction between the teacher and the student in the classroom during the theorical and laboratorial classes will allow adequate the student to acquire the objectives. Laboratory protocols and other discussions on case studies related to drugs and toxicants provide the consolidation of knowledge and enable students to solve problems related to the pharmacology and toxicology field. In addition, the use of a set of study materials purposely created, as well as tutorial sessions for inquiries will allow a high level of adjustment between the methodologies and objectives of the curricular unite. M1: Presentation and discussion of relevant theoretical concepts in the classroom – Achieve outcome O1 to O7. M2: Brainstorm on pertinent issues related to the matter exposed and in the resolution of exercises Achieve outcome O10. M3: Execution of laboratory protocols using current analytical methodologies – Achieve outcome O8 and O9. M4: Discussion of problems and relevant clinical cases – Achieve all outcomes. M6: Use of the e-learning platform to store and provide educational material to the student. Evaluation – Achieve all outcomes.
Reading:
1. Rang and Dale's pharmacology, JM Ritter, RJ Flower, G Henderson, YK Loke, D MacEwan, HP Rang (Eds), 9th edition, Elsevier, 2019. 2. Terapêutica Medicamentosa e suas Bases Farmacológicas (Manual de Farmacologia e Farmacoterapia), S Guimarães, D Moura, P Soares da Silva (Eds), 6ª edição, Porto Editora, 2014. 3. Goodman & Gilman´s The Pharmacological Basis of Therapeutics, LL Bruton, R Hilal-Dandan, BC Knollmann (Eds), 13th edition, McGraw-Hill Education, 2018. 4. Casarett & Doull's Toxicology: The Basic Science of Poisons. Curtis Klaassen, 9th Edition, McGraw-Hill, 2018 5. Toxicologia Forense, Félix Carvalho, Maria Lourdes Bastos, Ricardo Dinis (Eds.), 1ª edição, PACTOR - Grupo LIDEL, 2015.? 6. Goldfrank´s Toxicologic Emergencies. Flomenbaum N.E. (et al.) 10th Edition. McGraw-Hill, USA, 2015. 7. Clarke's Analysis of Drugs and Poisons. Moffat, Anthony C (ED) 4th edition, The Pharmaceutical Press, 2011.