Curricular Unit:Code:
Toxicology and Toxicological Analysis I844TAT1
Year:Level:Course:Credits:
3MasterPharmaceutical Sciences4 ects
Learning Period:Language of Instruction:Total Hours:
Winter SemesterPortuguese/English52
Learning Outcomes of the Curricular Unit:
The objective of this course is to provide students with knowledge about the parameters of risk assessment of xenobiotics, the importance of toxicokinetics and the factors that influence it in the biological activity of xenobiotics, the main mechanisms of xenobiotic toxicity in living systems and the in vivo and in vitro methods used to evaluate the toxicity of drugs and other toxic agents. It is aimed that the student develops the critical and reflective spirit and acquires skills that allow the updating and progress in the scientific domain and its practical application. In the practical-laboratory component it is intended that the student develops the ability to work in teams, the scientific and critical spirit and the skill in the execution and discussion of laboratory protocols.
Syllabus:
Dose-response relationship. Risk Assessement. NOEL, NOAEL and ADI. Antagonism and Potentiation; Additive and Synergistic Effects. Tolerance. Disposition of Toxic Compounds: Absorption, Distribution, Metabolism, Excretion and Transport. Phase-one, Phase-two and Phase-three Reactions. Extra-Hepatic Metabolism. Toxication and Detoxication. Enzyme Induction and Inhibition. Target Organs of Toxicity. Mechanisms of cytotoxicity.
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The syllabus is consistent with the objectives aimed at acquisition of segmented and oriented concepts of toxicology by encouraging the development of critical thinking and the student ability to apply knowledge acquired for resolving toxicological issues. The constant request of practical nature activities help to fulfill the the goals established.
Teaching Methodologies (Including Evaluation):
Form of educational performance: (i) presentation and discussion of relevant theoretical concepts in the classroom, (ii) brainstorm on pertinent issues related to the matter exposed in the classroom, (iii) self-study orientation of students by consulting annotated bibliography, and (iv) presentation and discussion of case studies to reinforce the the given theoretical knowledge.
The assessment is continuous and consists of two written tests in theoretical part and of one mini-test for intermediate evaluation, an oral presentation of research paper, one written test and student performance in laboratorial part.
Final grade= 60% theoretical part + 40% in practical part
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
The teaching methodologies are consistent with the objectives of the unit as they seek to provide students with knowledge related to fundamental concepts in Toxicology with regard to its scope, objectives and appropriate analysis of potentially toxic compounds.With the resolution of practical cases it is intended that students develop critical thinking and reflective skills to acquire and upgrade and progress in science and its practical application. In addition to essential reading listed herewith, each topic will be accompanied by specific recommended readings in order to engage in a debate and discussion enabling a throughout comprehension of the matters and formation of a critical approach.
Reading:
1.Casarett & Doull´s Toxicology: The Basic Science of Poisons. Klaassen C.D. (Ed.). 8th Edition. McGraw-Hill, New York, 2013.
2.Casarett & Doull´s Essentials of Toxicology, Klaassen C.D. (Ed.). Third Edition (Lange), 2015 ISBN 13: 9780071847087
3.Toxicologia Fundamental. Coord. Ricardo Jorge Dinis-Oliveira, Félix Dias Carvalho, Maria de Lourdes Bastos. - 1ª ed. - Lisboa: Lidel, 2018. - XVIII, 261 p. - ISBN 978-989-752-286-4
4.Principles of Biochemical Toxicology. Timbrell J. Fourth Edition. CRC Press, 2009.
5.Principles and Methods of Toxicology. Hayes A.W., Kruger C.L. (Eds.). Sixth Edition. CRC Press, 2014.