Curricular Unit:Code:
New Therapeutic Systems297NSTR
Year:Level:Course:Credits:
5MasterPharmaceutical Sciences5 ects
Learning Period:Language of Instruction:Total Hours:
Portuguese65
Learning Outcomes of the Curricular Unit:
According to the enormous development of new therapeutic systems in recent years, this Curricular Unit (CU) has the goal to provide students with essential knowledge relating to novel dosage forms intended for administration of drugs.
At the end of the CU student must:
- Know the limitations associated with the use of conventional dosage forms.
- Recognize the need of develop strategies to improve the bioavailability of new drugs.
- Distinguish the different types of forms and strategies of modified drug release.
- Know various systems of encapsulation of active substances.
- Identify and characterize different colloidal systems: liposomes; micelles; nanoemulsions; Polymeric, Lipid, Protein and Metal Nanoparticles; Drug nanocrystals; Dendrimers and Fullerenes.
- Understand the advantages and limitations of new therapeutic systems for clinical application.
- Acquire capacities of laboratorial preparation of these dosage forms.
Syllabus:
Units 1 and 2 teaching
1. Introduction to new therapeutic systems
2. Systems for modified drug release
2.1. Encapsulation systems for active substances
3. Types of nanosystems
3.1. Liposomes
3.2. Micelles
3.3. Micro and nanoemulsions
3.4. Nanoparticles: Polymeric, Lipid, Protein and Metallic
3.8. Drug nanocrystals
3.9. Dendrimers
3.10. Fullerenes
4. Methods of characterization of nanosystems
5. Other strategies for modified release: smart polymers, cyclodextrins
6. Modified release dosage forms
Teaching Unit 3
1. Literature research regarding a new dosage form for the administration of drugs.
2. Oral presentation of research work.
3. Laboratorial preparation of lipid nanoparticles systems and modified release tablets
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
Students should acquire knowledge of the novel therapeutic systems and the importance of its development, taking into account the current clinical reality, with respect to new drug molecules. The need to develop new drug delivery systems, according to the limitations of conventional dosage forms will be explained.
Students will also be encouraged to deepen their knowledge about the new pharmaceutical forms for administration of drugs, with particular emphasis on pharmaceutical forms, which are already in clinical practice or in clinical trials, through literature.
Teaching Methodologies (Including Evaluation):
The evaluation of the theoretical component comprises the execution of two written tests. The final classification will be calculated using the average of the results obtained in the two written tests (2 ECTS). The minimum passing classification is 9,5.
For the student to be evaluated in the theoretical component of the Course Unit (CU), must attend at 50% of classes.
The evaluation of the laboratory component comprises: a continuous evaluation of the autonomous execution of theoretical-practical and laboratory work (20%); execution of a writing test (40%); oral presentation of a research work (40%).
The minimum passing classification for the laboratory component of the CU is 9.5 (2 ECTS).
For the student to be evaluated for the CU, must attend at 80% of the laboratory classes.
The approval of the CU is obtained by the average (higher than 10) of the theoretical (80%) and laboratory (20%) components.
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
The lectures will be taught using the expository method of teaching and questioning. The syllabus of teaching units 1 and 2 will be presented in a descriptive manner, supported by slideshow. The theoretical-practical and laboratory classes will be taught using the method statement and execution of experimental work, related to the topics covered in lectures. The teacher will clarify the doubts and guide the student study. The evaluation of the Curricular Unit (CU) will be conducted in accordance with the general UFP pedagogical rules. The knowledge acquired by the student will be checked by evaluating the theoretical and the laboratory component of the CU. All activities with evaluative nature (ECTS) duly proportionate to the total number of credits will be awarded to the CU. The ECTS provided for work-study student will only be fully allocated or not, depending on the performance demonstrated by the student, in particular with respect to the acquisition of knowledge and skills covered by the CU.
Reading:
1. Souto, E.B. and Lopes, C.M., Novas Formas Farmacêuticas para Administração de Fármacos, Fundação Fernando Pessoa, 2011
2. Farmacopeia Portuguesa 9, 2008
3. Silva, A.C., et al. (2012). Curr Med Chem, 19 (26): 4495 - 4510
4. Silva, A.C., et al. (2013). Curr Pharm Des, 19 (41):7185-95.
5. Silva, A.C., et al. (2015). Curr Drug Metabol, 16 (1): 3-16
6. Silva, A.C., et al. (2015). Curr Pharm Biotech 16 (4): 291-302
7. Silva, A.C., et al. (2015). Curr Pharm Biotech 16 (11): 940-954
8. Silva, A.C., et al. (2015). Curr Pharm Biotech, 16 (11): 955-965
9. Duncan, R. and Gaspar, R. (2011). Molecular Pharm, 8 (6): 2101–2141
10. Sonke Svenson (2014).WIR: Nanomed Nanobiotech
12. Matthias Wacker (2013). Int J Pharm, 457: 50-62
13. Weissig, V. et al. (2014), Int J Nanomed, 9: 4357–4373
14. Chen, H. et al. (2011). Drug Discov Today, 16: 354-360
15. http://www.fda.gov/ForConsumers/default.htm
16. https://www.edqm.eu/en/european-pharmacopoeia-8th-edition-1563.html
17. www.malvern.com