Curricular Unit:			Code:
Pharmacology I			844FAR1
Year:	Level:	Course:	Credits:
2	Master	Pharmaceutical Sciences	5 ects
Learning Period:		Language of Instruction:	Total Hours:
		Portuguese/English	65
Learning Outcomes of the Curricular Unit:
The main objectives of Pharmacology I are the learning of the fundamentals of Pharmacology and to correlated them to the Pharmacist daily practice, in particular: O1- Understand the basis of pharmacology and differentiate a drug from a medicine; O2- Knowing the all cycle for placing a drug into the market; O3- Understand the basic and clinical pharmacokinetics; O4- Understand the general mechanisms of drugs action; O5- Knowledge of the mechanisms by which drug interactions occur, as well as interactions among drugs and plants or food; O6- Identify the drugs and where they act and allocate them to their respective group; O7- Identify adverse drug reactions and understand the pharmacist role in pharmacovigilance; O8- Acquire the skills for analyzing pharmacology laboratory experiments; O9- Develop autonomy in the search for drug related information.
Syllabus:
CP1: General principles of Pharmacology, Drug versus medicine. CP2: Drug’s pathways in the body (ADME). Basic pharmacokinetics (absorption, distribution, metabolism and elimination), and clinical pharmacokinetics. CP3: Pharmacodynamics and general mechanisms of drugs action. CP4: Drugs acting at the central nervous system: (sedative and hypnotic, antidepressants, psychostimulants and drugs of abuse). CP5: Drugs acting on pain control: opioid analgesics and nonsteroidal anti- inflammatory drugs. CP6: Autonomic pharmacology. CP7: Animal experimentation and 3R rule. Viewing of representative videos concerning pharmacological experiments. CP8: Simulation of animal experiments using informatics software: Virtual Organ Bath Simulation® CP9: Preclinical studies and clinical trials. CP10: Adverse drug reactions and pharmacovigilance. CP11: Sources of drug Information.
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The contents comprising the curricular unit of Pharmacology I provide the students of Pharmaceutical Sciences the acquisition of scientific, technical and interpersonal skills to develop the Pharmacist interventions in the field of Pharmacology. Knowing the basics of pharmacology and also the major pharmacotherapeutic groups (syllabus contents CP1 to CP6) allow the student to achieve the objectives O1, O2, O3, O4, O5 and O6. The exposure of contents on clinical trials and pharmacovigilance (syllabus CP9 to CP11) allows the student to achieve the objectives O7 and O9. The simulation of pharmacological experiments using informatics software and viewing videos of basic pharmacological experiments (syllabus contents CP7 and CP8) are important for objectives O8 and O9, implementing a critical spirit in the student for laboratory experiments in pharmacology.
Teaching Methodologies (Including Evaluation):
Teaching Methodologies M1: Presentation and discussion of relevant theoretical concepts in the classroom M2: Brainstorm on pertinent issues related to the matter exposed and in the resolution of exercises M3: Simulation of animal experiments using computer software M4: Analysis and discussion of scientific articles about pharmacology experiments M5: Discussion of problems and relevant clinical cases. M6: Use of the e-learning platform to store and make educational material available to the student. Evaluation Students will be assessed with two written tests (1 hour each), with a 95% contribution to the final grade. In addition, classroom performance will be evaluated, in particular the resolution of training exercises and the completion of pharmacology protocols, contributing with 5% for the final grade. If the average of the two written tests is less than 9.5 the student will be automatically enrolled in the exam.
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
The constant interaction between the teacher and the student in the classroom will allow adequate the student to acquire the objectives. In addition, the use of a set of study materials purposely created, as well as tutorial sessions for inquiries will allow a high level of adjustment between the methodologies and objectives of the course. M1: Presentation and discussion of relevant theoretical concepts in the classroom – Achieve outcome O1 to O7. M2: Brainstorm on pertinent issues related to the matter exposed and in the resolution of exercises – Achieve outcome O9. M3: Simulation of animal experiments using computer software – Achieve outcome O8. M4: Analysis and discussion of scientific articles about pharmacology experiments – Achieve outcome O8 and O9. M5: Discussion of problems and relevant clinical cases – Achieve all outcomes. M6: Use of the e-learning platform to store and make educational material available to the student – Achieve all outcomes.
Reading:
1. Rang and Dale's pharmacology, JM Ritter, RJ Flower, G Henderson, YK Loke, D MacEwan, HP Rang (Eds), 9th edition, Elsevier, 2019. 2. Terapêutica Medicamentosa e suas Bases Farmacológicas (Manual de Farmacologia e Farmacoterapia), S Guimarães, D Moura, P Soares da Silva (Eds), 6ª edição, Porto Editora, 2014. 3. Basic & Clinical Pharmacology, BG Katzung (Ed), 14th edition, McGraw-Hill Education, 2018. 4. Goodman & Gilman´s The Pharmacological Basis of Therapeutics, LL Bruton, R Hilal-Dandan, BC Knollmann (Eds), 13th edition, McGraw-Hill Education, 2018.