Curricular Unit:Code:
Immunology843IMUN
Year:Level:Course:Credits:
3MasterPharmaceutical Sciences4 ects
Learning Period:Language of Instruction:Total Hours:
Winter SemesterPortuguese/English52
Learning Outcomes of the Curricular Unit:
Knowledge: The unit aims at providing the student with: comprehension of the basic mechanisms of the immune response to endogenous and exogenous aggressions; knowledge of the Immune System- organs, anatomy and cells; knowledge of the major humoral components of the IS, their molecular structure, function and mechanism of action; comprehension of Immunology of the infection; comprehension of immunodeficiencies, hypersensitivities, autoimmunities, tumors and transplants; understand immunization and immunosuppression; understand the strategies of therapeutic immunological manipulations; understand the major laboratory methods to the study of the immune system and the analytical methods of evaluation of its components.
Skills and capacities: Provide the student with practical skills to design, execute, interpret and validate Clinical and Research immunology laboratory results in the área of pharmacology.
Syllabus:
Basic notions of the immune system: acute phase response, inflammation, Complement system. Adaptive Immune system: T and B lymphocyte maturation, activation and differentiation; T and B cell populations; TCR and Ig genetic diversity; Antigen presenting cells (APC) and dendritic cells; MHC function and Antigen Presentation; Major Cytokines and their functions; Acute and chronic inflammation; Immune Response to viral, bacterial and parasitic infections; Active and passive Immunization; Primary and secondary immunodeficiencies; Hypersensitivities; Tumor Immunology; tolerance and autoimmunity.
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The course will consist in a approach of all the physiological basis of the immune system. Students will learn the “what and why” the several immune components come together to produce the immune response and its Effector systems. We will study the imbalances- pathologies of the immune system. We will conclude with the study of the cellular and humoral components of the immune system as a bridge to modern therapeutics.All the theorical knowledge will be transported to the practice classes with the study of the basis immunological tools- laboratorial immunoassays- used in laboratory diagnosis of immune diseases and immune status of a person.
Teaching Methodologies (Including Evaluation):
Theoretical Classes- these classes will cover the totality of the programmatic contente, using the expositive method. During the teoric sessions will be incentivated the students participations, co-relating the concepts he leaned with ethical and pratical aspects of its future professional life; there will be a solid transmission of all the teoric knowledge in a progressive and contínuos form.
Pratical Classes; the laboratorial works concerning the study of the immunological status will be developed with the intention to give to the sudent the adequate skills in a clinical immunology laboratory.
Evaluation: the evaluation used is iin the Pedagogical Regulation Manual- 80% of the final grade will result from the teorical tests (2 writen evaluations) medium; 20% of the final grade will result from the practical componente (scientific article-1/3, a test-1/3 and individual participation-1/3)
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
Teorical Component- the student and the teacher will discuss the information exposed in the main text book, and the transmited concepts; short questions will evaluate if the student is making progresses and also the tests will evaluate its performance. The classes will be suported by periods of individual or group tutorial sessions that will satisfy the main necessities of the student. Pratical Component- The student shoul be able to adapt to the laboratorial environment and equipements used in the several immunologic diagnostic tecnhiques; he should be able to answer basic questions of the laboratory assays and develop its capacity to mantain an oral discussion, namely of cientific works in his área; he should be able to analize the recente literature and explain its importance in the investigation context.
Reading:
Fundamentos de Imunologia (2012) Autor(es) Fernando A. Arosa, Elsa M. Cardoso e Francisco C. Pacheco Arosa et al. Lidel, (2ª Edição)
Kuby Immunology (2004) Autores Richard A. Goldsby, Thomas J. Kindt, Barbara A. Osborne, Janis. Freeman (5ª edição)
Medical Immunology (2001) Autores Tristram G. Parslow, Daniel P. Stites, Abba I. Terr, John B. Imboden, McGraw-Hill (10º edição)
Current Protocols in Immunolology (1991), Wiley Interscience, Ed John Colingan