Curricular Unit:Code:
Applied Biochemistry248BQAP
Year:Level:Course:Credits:
2MasterPharmaceutical Sciences4 ects
Learning Period:Language of Instruction:Total Hours:
Portuguese52
Learning Outcomes of the Curricular Unit:
The aim of the course is to establish correlations between the cellular metabolic functioning and the physiopathological syndromes that involve metabolic changes. It is important that the students are capable to explain the appearing of a disease, its symptoms and its possible interruption by therapeutic, through the biochemical laws.
Syllabus:
1. Conjunctive Tissue Biochemistry (Uronic acids metabolism; Glycosaminoglycans; Diseases) 2. Lipids of Membranes Metabolism (Phospholipids and sphingolipids metabolism; Diseases) 3. Amino Acids Metabolism (Synthesis and degradation of amino acids; Neurotransmitters; Diseases) 4. Proteins Metabolism 5. Iron Metabolism (Intestinal absorption of iron; Heme biosynthesis and catabolism; Hemoglobin, myoglobin and other hemoproteins; Oxygen and carbon dioxide transport; Diseases) 6. Nucleotides Metabolism (Purine nucleotide metabolism; Pyrimidine nucleotide metabolism; Diseases) 7. Xenobiotics Metabolism 8. Enzymes 9. Vitamins and Coenzymes
Demonstration of the Syllabus Coherence with the Curricular Unit's Objectives:
The syllabus comprising the curricular unit meet the requirements that are set out in the objectives. The aim of the course is to establish correlations between the cellular metabolic functioning and the physiopathological syndromes that involve metabolic changes. Students should have the capacity of comprehension and acquisition of knowledge in the area of the structural and metabolic Biochemistry.
Students are also requested to acquire and develop empirical abilities during the contact with new laboratorial methodologies.
Teaching Methodologies (Including Evaluation):
In the theoretical classes the relevant theoretical concepts are exposed and the students study is supervised by consultation of the recommended bibliography. The theoretical classes also include the detailed discussion, with the resolution of exercises, about the principal subjects, including the analysis of metabolic diseases, their symptoms and relation with the causes and the possible treatments.
The laboratorial practical classes include the execution of practical works of application of the several theoretical concepts.
Theoretical (80%): 2 tests (50% each); Practical (20%): 3 mini-tests (15% each), 3 reports (15% each) and performance in the laboratory (10%)
Demonstration of the Coherence between the Teaching Methodologies and the Learning Outcomes:
In a first phase, it is important that the students are capable to explain the appearing of a disease, its symptoms and its possible interruption by therapeutic, through the biochemical laws. As such, in the theoretical classes the relevant theoretical concepts are exposed and the students study is supervised by consultation of the recommended bibliography. In a second phase, some clinical situations are introduced, related to changes in metabolic pathways studied. For that, the theoretical classes also include the detailed discussion, with the resolution of exercises, about the principal subjects, including the analysis of metabolic diseases, their symptoms and relation with the causes and the possible treatments. Students are also requested to acquire and develop empirical abilities during the contact with new laboratorial methodologies. As such, the laboratorial practical classes include the execution of practical works of application of the several theoretical concepts.
Reading:
(1) Devlin, T.M., 2006. “Textbook of Biochemistry with Clinical Correlations”. 6ª edição, N.Y., Wiley-Liss.
(2) Nelson, D.L.; Cox, M.M., 2013. “Lehninger Principles of Biochemistry”. 6ª edição, N.Y., W.H. Freeman and Company.
(3) Mckee, T.; Mckee, J.R., 2008. “Biochemistry: the Molecular Bases of Life”. 4ª edição, N.Y., McGraw-Hill.
(4) Berg, J.M.; Tymoczko, J.L.; Stryer L., 2006. “Biochemistry”. 6ª edição, N.Y., W.H. Freeman and Company.
(5) Leal, F.; Cardoso, I.L., 2013. “Casos Clínicos em Bioquímica”. edições UFP.
(6) Cardoso, I.L.; Leal, F., 2013. “Manual de Exercícios de Bioquímica”. edições UFP.
(7) Cardoso, I.L. et al., 2014. “Trabalhos Laboratoriais de Bioquímica”. 3ª edição, edições UFP.
(8) Leal, F.; Cardoso, I.L., 2018. “Sistema Endócrino e Patologias Associadas”. Lusodidacta.